GSM2547138[Accession] - GEO DataSets

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Items: 4

Select item 2000971171.

Integrated target discovery screens identify IL11 as novel therapeutic target for fibrosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL19057 GPL18573
212 Samples

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Accession:: GSE97117

ID:: 200097117

PubMed Full text in PMC Similar studies

Select item 2000969752.

Integrated target discovery screens identify IL11 as novel therapeutic target for fibrosis [human]

(Submitter supplied) Cardiac fibrosis is the final common pathology in heart disease. Here we establish an integrated imaging-genomic discovery platform using primary human heart fibroblasts to identify new drug targets for cardiac fibrosis. Genome wide analyses identify IL11, a secreted cytokine amenable to therapeutic inhibition, as the leading pro-fibrotic candidate. We demonstrate an autocrine loop of IL11 activity that is critical for fibrosis and acts as a nexus of signalling convergence for multiple pro-fibrotic stimuli. more...