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Items: 4

1.

Integrated target discovery screens identify IL11 as novel therapeutic target for fibrosis [168 human cardiac fibroblasts]

(Submitter supplied) Cardiac fibrosis is the final common pathology in heart disease. Here we establish an integrated imaging-genomic discovery platform using primary human heart fibroblasts to identify new drug targets for cardiac fibrosis. Genome wide analyses identify IL11, a secreted cytokine amenable to therapeutic inhibition, as the leading pro-fibrotic candidate. We demonstrate an autocrine loop of IL11 activity that is critical for fibrosis and acts as a nexus of signalling convergence for multiple pro-fibrotic stimuli. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
168 Samples
Download data: TXT
2.

Integrated target discovery screens identify IL11 as novel therapeutic target for fibrosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL18573 GPL19057
212 Samples
Download data: CSV
Series
Accession:
GSE97117
ID:
200097117
3.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
4.

Pa080BS

Organism:
Homo sapiens
Source name:
right atrial appendage biopsies
Platform:
GPL16791
Series:
GSE97117 GSE97358
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Sample
Accession:
GSM2562647
ID:
302562647
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