GSM2916056[Accession] - GEO DataSets

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Items: 4

Select item 2001089221.

Genome-wide maps of chromatin state and Gene Expression Profiling in HCT116 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL11154
74 Samples

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Series

Accession:: GSE108922

ID:: 200108922

PubMed Full text in PMC Similar studies

Select item 2001089212.

Gene Expression Profiling of WT and KDM3A Knocked out Cell

(Submitter supplied) We identified KDM3A, a demethylase of histone H3K9me1/2, as a positive regulator for hippo target genes. We found that H3K27ac upregulation is highly correlated with gene activation, but not H3K4me3; and transcription repression of certain TEAD1 target genes, such as BBC3, is important for the pathway function. KDM3A knockout caused upregulation of H3K9me2 mainly on TEAD1-binding enhancers rather than gene bodies, leading to decrease of H3K27ac and TEAD1 binding on enhancers and impaired transcription.