GSM3141507[Accession] - GEO DataSets

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Items: 4

Select item 2001144231.

Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL21103 GPL9250
27 Samples

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Accession:: GSE114423

ID:: 200114423

PubMed Full text in PMC Similar studies

Select item 2001144222.

Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model (MBD-seq)

(Submitter supplied) We found that LP daughters have lower birthweight, alterations in mammary gland morphology and higher rates of mammary cancer. Further, we found that mammary glands and tumors of LP daughters are metabolic rewired, with alterations in the AMPK and amino-acid metabolism pathways. These changes were associated with differential expression of miRNAs 451a, miR-200c and miR-92a. Importantly, some of the same miRNAs and target genes alterations were detected in breast tumors of women from populations with high rates of low birthweight.