GSM3184384[Accession] - GEO DataSets

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Items: 4

Select item 2001169541.

A lamina-associated domain border governs nuclear lamina interactions, transcription and recombination of the Tcrb locus.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL17021 GPL21103
17 Samples

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Accession:: GSE116954

ID:: 200116954

PubMed Full text in PMC Similar studies

Select item 2001155822.

A lamina-associated domain border governs nuclear lamina interactions, transcription and recombination of the Tcrb locus [ChIP-seq]

(Submitter supplied) Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here we used DamID to profile Tcrb locus interactions with the nuclear lamina at high-resolution. We identified a lamina-associated domain (LAD) border composed of several CTCF binding elements that segregates active non-LAD from inactive LAD regions of the locus. Deletion of the LAD border caused an enhancer-dependent spread of H3K27ac from the active recombination center into recombination center-proximal LAD chromatin. more...