GSM3429000[Accession] - GEO DataSets

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Items: 3

Select item 2001212641.

Tau drives translational selectivity by interacting with ribosomal proteins

(Submitter supplied) There is a fundamental gap in understanding the consequences of tau-ribosome interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and they associate strongly with ribosomes in vivo. Here, we investigated the consequences of tau interactions with ribosomes in vivo and in human brain tissues to identify tau as a direct modulator of ribosomal selectivity. We performed microarrays and nascent proteomics to measure changes in protein synthesis using rTg4510 tau transgenic mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL20775
12 Samples

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Accession:: GSE121264

ID:: 200121264

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000207752.

[MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version]

(Submitter supplied) Annotation was derived from the Affymetrix annotation file MTA-1_0.na35.mm10.transcript.csv: #%create_date=Wed Apr 1 16:56:09 2015 PDT #%chip_type=MTA-1_0 #%lib_set_name=MTA-1_0 #%lib_set_version=r1 #%genome-species=Mus musculus #%genome-version=mm10 #%genome-version-ucsc=mm10 #%genome-version-ncbi=38 #%genome-version-create_date=2011-12-00 #%genome-lifted-method=psl-map.pl #%genome-lifted_from-species=Mus musculus #%genome-lifted_from-version-ucsc=mm10 #%genome-lifted_from-version-ncbi=38 #%netaffx-annotation-date=2014-10-31 #%netaffx-annotation-netaffx-build=35 Protocol: See manufacturers website