GSM3660024[Accession] - GEO DataSets

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Items: 4

Select item 2001280011.

AMPK links acetyl-coA homeostasis to BET recruitment in acute myeloid leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24247 GPL19057
30 Samples

Download data: BEDGRAPH

Series

Accession:: GSE128001

ID:: 200128001

Select item 2001280002.

AMPK links acetyl-coA homeostasis to BET recruitment in acute myeloid leukemia: ChIP-seq

(Submitter supplied) Altered metabolism fuels two hallmark properties of cancer cells, unlimited proliferation and differentiation blockade. AMP-activated protein kinase (AMPK) is a master regulator of bioenergetics crucial for glucose metabolism in acute myeloid leukemia (AML) and its inhibition delays leukemogenesis, but whether the metabolic function of AMPK alters AML epigenome remains unknown. Here, we demonstrate that AMPK maintains the epigenome of MLL-rearranged AML by linking acetyl-CoA homeostasis to BET bromodomain protein recruitment to chromatin. more...