GSM37107[Accession] - GEO DataSets

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Items: 4

Select item 2000020421.

Apoptosis and differentiation commitment:novel insights revealed by gene profiling studies in mouse Embryonic Stem cells

(Submitter supplied) Mouse embryonic stem (ES) cells remain pluripotent in vitro when grown in presence of Leukaemia Inhibitory Factor (LIF). LIF starvation leads to apoptosis of some of the ES-derived differentiated cells, together with p38a MAP kinase activation. Apoptosis, but not morphological cell differentiation, is blocked by a p38 inhibitor, PD 169316. To further understand the mechanism of action of this compound, we have identified its specific targets by microarray studies. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS1593 GDS1596
Platforms:: GPL32 GPL81
13 Samples

Download data: CEL, EXP

Series

Accession:: GSE2042

ID:: 200002042

Select item 15932.

p38 inhibitor PD169316 effect on embryonic stem derived differentiated cells (U74A Version 1)

Analysis of embryonic stem cells differentiated in the presence of PD169316, an inhibitor of p38 that blocks apoptosis without altering differentiation. Results identify gene families whose transcriptional regulation correlates with cell fate: differentiation with or without apoptosis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 2 cell line sets

Platform:: GPL32
Series:: GSE2042
6 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1593

ID:: 1593

Select item 1000000323.

[MG_U74A] Affymetrix Murine Genome U74A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 21, 2012: annotation table updated with netaffx build 32 July 06, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The MG-U74 version 1 set comprises three arrays representing over 36,000 mouse genes and ESTs. more...