GSM372031[Accession] - GEO DataSets

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Items: 4

Select item 2000148881.

Conjugated linoleic acid activates AMPK and reduces adiposity more effectively when used with metformin

(Submitter supplied) Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) causes dramatic reductions in white adipose tissue in mice but has had limited effectiveness in humans. Determination of the signaling pathways involved may lead to better regulation of adiposity. T10c12 CLA was found to activate AMP-activating protein kinase (AMPK), a central regulator of cell metabolism. Compound C, a potent inhibitor of AMPK, prevents many of the typical responses to treatments with t10c12 CLA including the integrated stress response (ISR), the inflammatory response, the reduction in key lipogenic transcription factors, and delipidation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3808
Platform:: GPL1261
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE14888

ID:: 200014888

Select item 38082.

Trans-10, cis-12 conjugated linoleic acid and metformin effect on 3T3-L1 adipocytes

Analysis of adipocytes treated with trans-10, cis-12 conjugated linoleic acid in conjunction with AMPK activator metformin. The combined treatment results in greater triglyceride (TG) reduction than with the individual chemicals. Results provide insight into molecular basis of the TG reduction.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 agent sets

Platform:: GPL1261
Series:: GSE14888
12 Samples

Download data: CEL

DataSet

Accession:: GDS3808

ID:: 3808

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...