GEO DataSets

(Submitter supplied) Yin Yang 1 (YY1) is a critical transcription factor controlling cell proliferation, development and DNA damage responses. Although two homologous Drosophila YY family members (pleiohomeotic (pho)) and pleiohomeotic-like (phol)) are redundant, the functional significance of a recently described mammalian YY1-like gene (YY2) is unknown. Using microarray and gene set enrichment analysis (GSEA), we found that lentiviral constructs containing short hairpin loop YY1- and YY2-specific inhibitory RNAs (shYY1 and shYY2) caused significant changes in both redundant and distinguishable expression patterns. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3788

Platform:

GPL570

13 Samples

Download data: CEL, CHP

Analysis of HeLa cells following shRNA knockdown of zinc-finger transcription factor Yin Yang 1 (YY1), its homolog YY2, or both YY1 and YY2. YY1 plays a critical role in controlling cell proliferation, development and DNA damage responses. Results provide insight into YY2 versus YY1 target genes.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 genotype/variation sets

Platform:

GPL570

Series:

GSE14964

13 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5670 Series

61 Related Platforms

175576 Samples

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