GSM3737346[Accession] - GEO DataSets

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Items: 4

Select item 2001303901.

NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure adipocyte differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16417 GPL17021 GPL11002
57 Samples

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Accession:: GSE130390

ID:: 200130390

PubMed Full text in PMC Similar studies

Select item 2001303892.

NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure adipocyte differentiation [RNA-seq]

(Submitter supplied) The transcription factor nuclear factor I-A (NFIA) is a regulator of brown adipocyte differentiation. Here we show that the most C-terminal 17 amino acid residues of NFIA (which we named pro#3 domain) is required for transcriptional activity of NFIA. Full-length NFIA, but not deletion mutant lacking pro#3 domain rescued impaired Pparg expression and adipogenesis in NFIA-knockout cells. Mechanistically, the ability of NFIA to increase chromatin accessibility is mediated through pro#3 domain. more...