GEO DataSets

(Submitter supplied) The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a master regulator of this network when the inducing DNA lesions are double strand breaks. The ATM gene is also frequently mutated in sporadic cancers of lymphoid origin. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1544

Platform:

GPL81

14 Samples

Download data: CEL

Analysis of lymph nodes from ATM-deficient males exposed to ionizing radiation (IR). ATM regulates the cellular network induced by DNA double-strand breaks and is often mutated in lymphoid tumors. Results identify parallel induction of ATM-dependent pro- and antiapoptotic signals in response to IR.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 stress, 3 time sets

Platform:

GPL81

Series:

GSE2118

14 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The MG-U74 set includes 3 arrays with a total of 36899 entries and was indexed 29-Jan-2002. more...

Organism:

Mus musculus

264 DataSets

537 Series

1 Related Platform

6909 Samples

Download data