GSM3833246[Accession] - GEO DataSets

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Items: 4

Select item 2001319861.

Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Genome variation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL21290 GPL18573 GPL21493
223 Samples

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Accession:: GSE131986

ID:: 200131986

PubMed Full text in PMC Similar studies

Select item 2001319772.

Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer [Barcode]

(Submitter supplied) BET inhibitors are promising therapeutic agents for the treatment of triple-negative breast cancer (TNBC), but the rapid emergence of resistance necessitates investigation of combination therapies and their effects on tumor evolution. Here, we show that palbociclib, a CDK4/6 inhibitor, and paclitaxel, a microtubule inhibitor, synergize with the BET inhibitor JQ1 in TNBC lines. High-complexity DNA barcoding and mathematical modeling indicate a high rate of de novo acquired resistance to these drugs relative to pre-existing resistance. more...