GEO DataSets

(Submitter supplied) Immediate and early effects of transient hyperglycaemia were examined using fully- reversible transgenic diabetic mice. Transient hyperglycaemia altered expression of 769 arterial genes, of which 200 did not reverse following recovery from hyperglycaemia. Many such genes are known to promote atherogenesis, including several implicated in arterial calcification and inflammation. This supports the view that hyperglycaemia causes not only very early deleterious changes in arterial gene expression but that to a large extent these persist for some time after restoration of normal blood glucose levels in vivo. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4016

Platform:

GPL1261

18 Samples

Download data: CEL

Analysis of aorta of pIns-c-MycERTAM females treated with tamoxifen (c-Myc 'ON'; rendered transiently hypo- and then hyperglycemic) then not treated (c-Myc 'OFF'; recovery from hyperglycemia). Results provide insight into molecular effects on artery caused by short-term exposure to hyperglycemia.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 6 disease state, 6 time sets

Platform:

GPL1261

Series:

GSE15401

18 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4547 Series

40 Related Platforms

58950 Samples

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