GSM3896324[Accession] - GEO DataSets

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Items: 4

Select item 2001329151.

Senescence rather than apoptosis of alveolar progenitor cells drives pulmonary fibrosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL24676 GPL24247
32 Samples

Download data: H5

Series

Accession:: GSE132915

ID:: 200132915

PubMed Full text in PMC Similar studies

Select item 2001329142.

Senescence rather than apoptosis of alveolar progenitor cells drives pulmonary fibrosis (human)

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a fatal form of interstitial lung disease associated with progressive scarring of lung tissue and declining pulmonary function in aging individuals. Here we employ data mining and single cell RNA sequencing (scRNAseq) to define candidate drivers of AT2 senescence in IPF lung tissue. We show that AT2 cells isolated from IPF lung tissue exhibit characteristic features of cellular senescence and reduced abundance of Sin3a, critical determinant of endodermal progenitor cell maintenance in the developing lung. more...