GSM3912555[Accession] - GEO DataSets

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Items: 4

Select item 2001336001.

The RNA N6-methyladenosine regulates chromatin remodeling and transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL19057 GPL24247 GPL21103
122 Samples

Download data: NARROWPEAK, TXT

Series

Accession:: GSE133600

ID:: 200133600

PubMed Full text in PMC Similar studies

Select item 2001335852.

The RNA N6-methyladenosine regulates chromatin remodeling and transcription [seq_nuclearRNA]

(Submitter supplied) The N6-methyladenosine (m6A) has been shown to regulate stability and translation of messenger RNA (mRNA) in various biological processes. Here, we show that the knockout of the m6A writer Mettl3 or a nuclear reader Ythdc1 in mouse embryonic stem cells (mESCs) induces chromatin openness and transcription activation in an m6A-dependent manner. We identified extensive m6A modifications on caRNAs (chromosome-associated RNAs, including promoter-associated RNAs, enhancer RNAs and repeats) that are installed by METTL3. more...