GSM391302[Accession] - GEO DataSets

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Items: 3

Select item 2000156301.

Multiomics study to identify virulence factors of Rickettsia prowazekii revealed its adaptive mutation capabilities

(Submitter supplied) We identified four virulence phenotypes of Rickettsia prowazekii (the deadly agent of epidemic typhus) that are associated with the upregulation of antiapoptotic genes (virulent strain) or the Interferon I pathway (avirulent). Transcriptional and proteomic analyses of R. prowazekii linked surface protein expression and methylation with virulence. By sequencing a virulent strain and using comparative genomics, we found hotspots of mutations in homopolymeric tracts of poly(A) and poly(T) that lead to gene split and inactivation and explain the loss of virulence in the vaccine strain. more...

Organism:: Rickettsia prowazekii str. Rp22; Rickettsia prowazekii str. Madrid E; Rickettsia prowazekii

Type:: Expression profiling by array

Platform:: GPL8427
3 Samples

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Accession:: GSE15630

ID:: 200015630

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Select item 1000084272.

URMITE Rickettsia prowazekii array

(Submitter supplied) Oligonucleotide set of 1,411probes representing 545 intergenic regions and 867 ORFs of R.prowazekii madrid E strain. Protocol: Sure Print Technology-In situ synthesis