GSM3948552[Accession] - GEO DataSets

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Items: 4

Select item 2001344521.

The histone H3G34R mutation disrupts the epigenome via catalytic inactivation of the ASH1 H3K36 methyltransferase

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Neurospora crassa

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL23150 GPL20660 GPL16164
20 Samples

Download data: BIGWIG, IGV, TAB, TDF, XLSX

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Accession:: GSE134452

ID:: 200134452

Select item 2001344492.

The histone H3G34R mutation disrupts the epigenome via catalytic inactivation of the ASH1 H3K36 methyltransferase [ChIP-seq]

(Submitter supplied) The recurrent mutation of histone variant H3.3 at glycine-34 (H3.3G34) defines a type of pediatric glioma. Characteristic changes to the epigenome associated with the disease are thought to be the consequence of altered methylation of the adjacent lysine-36 (K36) residue, but the complexity of this regulatory pathway in humans, combined with a multi-component disease etiology, has limited our understanding of how H3.3G34 mutations contribute to oncogenesis. more...