GSM4034929[Accession] - GEO DataSets

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Items: 4

Select item 2001611201.

Impaired CHD6 function links misregulation of autophagy and DNA damage response to premature ageing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
55 Samples

Download data: BED, BW, TDF, TXT

Series

Accession:: GSE161120

ID:: 200161120

PubMed Full text in PMC Similar studies

Select item 2001358322.

Impaired CHD6 function links misregulation of autophagy and DNA damage response to premature ageing [RNA-Seq]

(Submitter supplied) Members of the Chromodomain-Helicase-DNA binding (CHD) protein family are chromatin remodelers critically implicated in human pathologies. CHD6 is the least studied member of this family, and we were motivated to dissect its in-cell roles by discovering a mutated CHD6 allele in a patient suffering from the rare Hallermann-Streiff premature aging syndrome (HSS). We generated isogenic iPSC lines carrying (or not) this single point mutation in the CHD6 SANT/SLIDE domain, which allow studying HSS-relevant cell identities. more...