GSM4051472[Accession] - GEO DataSets

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Items: 4

Select item 2001364241.

CDK-Mediator and FBXL19 cooperate in the induction of developmental genes by promoting regulatory interactions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL19057 GPL25537
76 Samples

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Series

Accession:: GSE136424

ID:: 200136424

PubMed Full text in PMC Similar studies

Select item 2001364232.

CDK-Mediator and FBXL19 cooperate in the induction of developmental genes by promoting regulatory interactions [CaptureC]

(Submitter supplied) Appropriate developmental gene regulation relies on the capacity of gene promoters to integrate inputs from distal regulatory elements, yet how this is achieved remains poorly understood. In embryonic stem cells (ESCs), a subset of silent developmental gene promoters are primed for activation by FBXL19, a CpG island binding protein, through its capacity to recruit CDK-Mediator. How mechanistically these proteins function together to prime genes for activation during differentiation is unknown. more...