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Items: 3

1.

Mutant FOXL2C134W hijacks SMAD4 and SMAD2/3 to drive adult granulosa cell tumors

(Submitter supplied) The FOXL2 mutant C134W occurs in virtually all adult ovarian granulosa cell tumors (AGCT), and is considered a driver of oncogenesis in this disease. However, the mechanism by which FOXL2C134W contributes to tumorigenesis is not known. Here, we show that mutant FOXL2C134W acquires the ability to bind SMAD4, forming a FOXL2C134W/SMAD4/SMAD2/3 complex that binds a novel hybrid DNA motif AGHCAHAA, unique to the FOXL2C134W mutant. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
105 Samples
Download data: TXT, WIG
Series
Accession:
GSE138496
ID:
200138496

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12866 Series
347478 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

RNA-seq_Exp6_HGrC1_C134W_TGF_rep3

Organism:
Homo sapiens
Source name:
HGrC1 cell-line
Platform:
GPL18573
Series:
GSE138496
Download data
Sample
Accession:
GSM4109886
ID:
304109886

SRA Run Selector

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db=gds|term=GSM4109886[Accession]|query=1|qty=2|blobid=MCID_678f3a923ebf2117040c5682|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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