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Items: 3

1.

Global discovery of SLE genetic risk variant allelic enhancer activity

(Submitter supplied) Genome-wide association studies of Systemic Lupus Erythematosus (SLE) nominate 3,073 genetic variants at 91 risk loci. To systematically screen these variants for allelic transcriptional enhancer activity, we constructed a massively parallel reporter assays (MPRA) library comprising 12,396 DNA oligonucleotides containing the genomic context around every allele of each SLE variant. Transfection into Epstein-Barr virus-transformed B cell line GM12878 revealed 482 variants with enhancer activity, with 51 variants showing genotype-dependent (allelic) enhancer activity at 27 risk loci. more...
Organism:
Homo sapiens; unidentified plasmid
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL28010 GPL18573 GPL24676
25 Samples
Download data: TXT, XLSX
Series
Accession:
GSE143792
ID:
200143792

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12876 Series
347577 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

SLE_GM12878_3

Organism:
Homo sapiens
Source name:
EBV transformed B cell line
Platform:
GPL18573
Series:
GSE143792
Download data: TXT
Sample
Accession:
GSM4274714
ID:
304274714

SRA Run Selector

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db=gds|term=GSM4274714[Accession]|query=1|qty=3|blobid=MCID_679255053ebf211704c772ce|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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