GSM4286068[Accession] - GEO DataSets

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Items: 4

Select item 2001449041.

Genome-wide investigation of the dynamic changes of epigenome modifications after DNA methylation editing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21290 GPL16791
48 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE144904

ID:: 200144904

PubMed Full text in PMC Similar studies

Select item 2001443312.

Genome-wide investigation of the dynamic changes of epigenome modifications after DNA methylation editing [MBD-seq]

(Submitter supplied) The aim of this study was to investigate the stability of DNA methylation, the dynamics of different histone modifications and the changes in expression after genome-wide introduction of DNA methylation in promotor CpG islands. Therefore, the catalytic domain of DNMT3A was fused to a zinc finger protein and expressed for three days to globally introduce de novo DNA methylation and subsequently, the changes in the epigenome were monitored for up to eleven days.