GSM434221[Accession] - GEO DataSets

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Items: 3

Select item 2000173061.

Plasma cells from 52 patients with multiple myeloma: mRNA and miRNA expression profiling

(Submitter supplied) We used microarray analyses of patient myeloma cells (n=52) to correlate individual miRNA expression profiles with GEP-based risk defined by mRNA expression profilesx as well as clinical features of the disease. Unlike for mRNAs, genome-wide elevation of miRNA expression patterns were significantly positively associated with a mRNA-based GEP-risk score (P <.01) and proliferation index (P <.05). Consistent with our observation of global deregulation of miRNA expression profiles, silencing EIF2C2/AGO2, a gene component of the mRNA-based high-risk signature and a master regulator of the genesis and functionality of all miRNAs, dramatically decreased viability in myeloma cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL570 GPL9081
106 Samples

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Accession:: GSE17306

ID:: 200017306

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000090812.

Agilent-016436 Human miRNA Microarray 1.0 G4472A (miRNA ID version)

(Submitter supplied) Human miRNA Microarrays, 8x15K, version 1 (G4472A) This platform is based on the GeneView file produced by Agilent's feature extraction software. Protocol: see manufacturer's web site at http://www.agilent.com/