GSM4365326[Accession] - GEO DataSets

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Items: 4

Select item 2001460971.

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
572 Samples

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Accession:: GSE146097

ID:: 200146097

PubMed Full text in PMC Similar studies

Select item 2001460962.

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity [DGE]

(Submitter supplied) Kinase inhibitors (KIs) represent an important class of anti-cancer drugs. Although cardiotoxicity is a serious adverse event associated with several KIs, the reasons remain poorly understood and its prediction remains challenging. Here, we perform transcriptomic profiling of human heart-derived primary cardiomyocyte cell lines treated with a panel of 26 FDA-approved KIs and classify their effects on subcellular pathways and processes. more...