GSM4412340[Accession] - GEO DataSets

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Items: 4

Select item 2001475021.

Heterogeneity of tissue-resident CD8+ T cells in response to infection and malignancy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL21103 GPL17021
51 Samples

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Series

Accession:: GSE147502

ID:: 200147502

PubMed Full text in PMC Similar studies

Select item 2001470212.

RNA-Seq of CD8+ T cell subsets during LCMV infection I

(Submitter supplied) Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous surveillance of non-lymphoid tissues. While the relevance of Trm in diverse diseases ranging from infection to cancer is appreciated, the development and functional heterogeneity of Trm remain poorly understood. Using single-cell RNA-sequencing (scRNA-seq) and genetic reporter mice, we identified discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections, and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection timepoints. more...