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Items: 4

1.

Subtype-Specific and Structure Variation-Induced Chromatin Spatial Reorganization in Acute Myeloid Leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing
Platforms:
GPL20795 GPL24676 GPL20301
135 Samples
Download data: BIGWIG, BW, MCOOL, PAIRS, TXT
Series
Accession:
GSE152136
ID:
200152136
2.

Subtype-Specific and Structure Variation-Induced Chromatin Spatial Reorganization in Acute Myeloid Leukemia [Hi-C]

(Submitter supplied) Acute myeloid leukemia (AML) is a set of heterogeneous myeloid malignancies hallmarked by mutations in epigenetic modifiers, transcription factors and kinases that can cause epigenetic reshaping. It is unclear whether those mutations drive chromatin 3D structure alteration and contribute to oncogenic dysregulation in AML. By performing Hi-C and whole genome sequencing in 21 primary AML and healthy donors’ samples, we identified recurrent AML- or subtype-specific alteration of compartments, TADs, and chromatin loops. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL24676
32 Samples
Download data: MCOOL, PAIRS
Series
Accession:
GSE152135
ID:
200152135
3.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
4.

260_Hi-C

Organism:
Homo sapiens
Source name:
Primary AML
Platform:
GPL24676
Series:
GSE152135 GSE152136
Download data: MCOOL, PAIRS
Sample
Accession:
GSM4604281
ID:
304604281
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