GSM4697090[Accession] - GEO DataSets

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Items: 4

Select item 2001551911.

DREAM represses distinct targets by cooperating with different THAP domain proteins

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL18730
81 Samples

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Series

Accession:: GSE155191

ID:: 200155191

PubMed Full text in PMC Similar studies

Select item 2001551902.

DREAM represses distinct targets by cooperating with different THAP domain proteins [RNA-seq]

(Submitter supplied) The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle and other genes, but its mechanism of action is unclear. Here we demonstrate that two C. elegans THAP domain proteins, LIN-15B and LIN-36, co-localize with DREAM and function by different mechanisms for repression of distinct sets of targets. LIN-36 represses classical cell cycle targets by promoting DREAM binding and gene body enrichment of H2A.Z. more...