GSM4955578[Accession] - GEO DataSets

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Items: 4

Select item 2000643731.

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL10558 GPL11154 GPL18573
93 Samples

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Series

Accession:: GSE64373

ID:: 200064373

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000643012.

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites [sequencing]

(Submitter supplied) Glucocorticoid receptor (GR) is an essential transcription factor (TF), controlling metabolism, development and immune responses. SUMOylation regulates chromatin occupancy and target gene expression of GR in a locus-selective manner, but the mechanism of regulation has remained elusive. Here, we identify the protein network around chromatin-bound GR by using selective isolation of chromatin-associated proteins and show that the network is affected by receptor SUMOylation, with several nuclear receptor coregulators and chromatin modifiers preferring interaction with SUMOylation-deficient GR and proteins implicated in transcriptional repression preferring interaction with SUMOylation-competent GR. more...