GEO DataSets

(Submitter supplied) We previously identified toll-like receptor 4 (Tlr4) as a candidate gene responsible for ozone (O3)-induced pulmonary hyperpermeability and inflammation. The objective of this study was to determine the mechanism through which TLR4 modulates O3-induced pulmonary responses and to utilize transcriptomics to determine TLR4 effector molecules. C3H/HeJ (HeJ; Tlr4 mutant) and C3H/HeOuJ (OuJ; Tlr4 normal), mice were exposed continuously to 0.3 ppm O3 or filtered air for 6, 24, 48 or 72 hr. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4585

Platform:

GPL339

24 Samples

Download data: CEL

Analysis of lung from Toll-like receptor 4 (Tlr4)-deficient, C3H/HeJ males exposed to 0.3 ppm ozone (O3) for up to 48hr. Tlr4 is involved in O3-induced pulmonary hyperpermeability and inflammation. Results provide insight into the molecular basis of Tlr4 modulation of O3-induced pulmonary responses.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 genotype/variation, 2 strain, 4 time sets

Platform:

GPL339

Series:

GSE20715

24 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip Mouse Genome 430A 2.0 Array is accessioned in GEO as GPL8321. June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Mouse Genome 430A Array is a single array representing approximately 14,000 well-characterized mouse genes that can be used to explore biology and disease processes. more...

Organism:

Mus musculus

142 DataSets

423 Series

2 Related Platforms

5328 Samples

Download data