GSM5290204[Accession] - GEO DataSets

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Items: 4

Select item 2001742921.

CRISPR activation and interference screens decode stimulation responses in primary human T cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: unidentified plasmid; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL28010 GPL18573
68 Samples

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Accession:: GSE174292

ID:: 200174292

PubMed Full text in PMC Similar studies

Select item 2001742552.

CRISPR activation and interference screens decode stimulation responses in primary human T cells [CRISPR]

(Submitter supplied) Regulation of cytokine production in stimulated T cells can be disrupted in autoimmunity, immunodeficiencies, and cancer. Systematic discovery of stimulation-dependent cytokine regulators requires both loss-of-function and gain-of-function studies, which have been challenging in primary human cells. We now report genome-wide CRISPR activation (CRISPRa) and interference (CRISPRi) screens in primary human T cells to identify gene networks controlling interleukin 2 and interferon gamma production. more...