GSM5391025[Accession] - GEO DataSets

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Items: 3

Select item 2001784321.

Expression data from SIRT6 knockout, young WT and old WT mice brains

(Submitter supplied) Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, SIRT6 levels/activity decline, which is accentuated in Alzheimer's patients. To understand SIRT6 roles in transcript pattern changes, we analyzed transcriptomes of young WT, old WT and young SIRT6-KO mice brains, and found changes in gene expression related to healthy and pathological aging. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6193
9 Samples

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Accession:: GSE178432

ID:: 200178432

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000061932.

[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [probe set (exon) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html #%create_date=Wed Mar 11 17:52:51 2009 PDT #%chip_type=MoEx-1_0-st-v1 #%lib_set_name=MoEx-1_0-st #%lib_set_version=v1 #%genome-species=Mus musculus #%genome-version=mm9 #%genome-version-ucsc=mm9 #%genome-version-ncbi=37 #%genome-version-create_date=2007-07 #%netaffx-annotation-date=2009-03-16 #%netaffx-annotation-netaffx-build=28 Protocol: See manufacturer's web site