GEO DataSets

(Submitter supplied) During bacterial pneumonia, alveolar epithelial cells are critical for maintaining gas exchange and providing antimicrobial as well as pro-immune properties. We previously demonstrated that leukemia inhibitory factor (LIF), an IL-6 family cytokine, is produced by type II alveolar epithelial cells (ATII) and is critical for tissue protection during bacterial pneumonia. However, the target cells and mechanisms of LIF-mediated protection remain unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21783

18 Samples

Download data: CEL

(Submitter supplied) Leukemia inhibitory factor (LIF) is a cytoprotective cytokine that reduces lung injury during pneumonia. The purpose of this study was to determine the influence of LIF on pneumonia-induced gene changes in lung epithelium. Mice received intratracheal instillations of vehicle (PBS) or Escherichia coli (10^6 CFU). Control IgG or anti-LIF specific IgG was included in the instillate. 24 hours after the challenge, lung epithelial cells (EpCAM+/CD45-) were sorted from enzymatic lung digests and used for RNA isolation and microarray analysis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21783

9 Samples

Download data: CEL

(Submitter supplied) This is identical to GPL6246 but a custom cdf environment was used to extract data. The cdf can be found at the link below.

Organism:

Mus musculus

4 Series

1 Related Platform

23 Samples

Download data: CDF, TAB, TXT