GEO DataSets

(Submitter supplied) Development of targeted therapeutics for hepatocellular carcinoma (HCC) remains a major challenge. We have previously demonstrated that constitutively photomorphogenic 1 (COP1), which regulates p53 activity by ubiquitination, is frequently overexpressed in human HCC. Here we examined whether molecular targeting of COP1 by small interfering (si) RNA can affect the course of HCC progression. COP1-1 was selected as the most effective target siRNAs in terms of growth inhibition and apoptotic induction in several HCC cell lines. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4831

Platform:

GPL6883

22 Samples

Download data: TXT

Analysis of Huh7, HepG2, and Hep3B hepatocellular carcinoma (HCC) cells depleted for the ubiquitin modulator COP1. COP1 regulates p53 activity by ubiquitination. p53 is wild type in HepG2, mutated in Huh7, and lacking in Hep3B. Results provide insight into the role of COP1 in HCC pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 cell line, 2 protocol sets

Platform:

GPL6883

Series:

GSE21955

22 Samples

Download data

(Submitter supplied) The HumanRef-8 v3.0 Expression BeadChip features up-to-date content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36.2, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. These should be submitted as part of a GEOarchive. more...

Organism:

Homo sapiens

8 DataSets

229 Series

3 Related Platforms

7128 Samples

Download data: BGX