GSM649488[Accession] - GEO DataSets

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Items: 4

Select item 2000264591.

High-throughput ectopic expression screen for tamoxifen resistance

(Submitter supplied) Resistance to tamoxifen in breast cancer patients is a serious therapeutic problem and major efforts are underway to understand underlying mechanisms. Resistance can be either intrinsic or acquired. We derived a series of subcloned MCF7 cell lines that were either highly sensitive or naturally resistant to tamoxifen and studied the factors that lead to drug resistance. Gene-expression studies revealed a signature of 67 genes that differentially respond to tamoxifen in sensitive vs. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4051
Platform:: GPL570
24 Samples

Download data: CEL, EXP

Series

Accession:: GSE26459

ID:: 200026459

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 40512.

Tamoxifen-resistant breast cancer cell line MCF7 subclones

Analysis of tamoxifen-sensitive and -resistant subclones of breast tumor MCF7 cells treated with estrogen (E), 4-hydroxy-tamoxifen (4-OHT), or E + 4-OHT. Success of 4-OHT therapy is limited by intrinsic and acquired drug resistance. Results provide insight into mechanisms leading to drug resistance.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 agent, 2 genotype/variation sets

Platform:: GPL570
Series:: GSE26459
24 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS4051

ID:: 4051

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...