GSM659130[Accession] - GEO DataSets

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Items: 4

Select item 2000268071.

The HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array; Expression profiling by SNP array; SNP genotyping by SNP array

Platforms:: GPL8490 GPL6244 GPL3720
36 Samples

Download data: CEL

Series

Accession:: GSE26807

ID:: 200026807

Select item 2000267892.

The HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (ALL-B and ALL-T)

(Submitter supplied) Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose dependent antiproliferative and apoptotic effect which was associated with an increase in the acetylation of H3 and H4 histone acetylation which was uniformly in every genetic subgroup of ALL. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE26789

ID:: 200026789

Select item 1000062443.

[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site