GEO DataSets

(Submitter supplied) The present research aimed to investigate peripheral blood gene expression profiling as a minimally invasive surrogate approach to study silica-induced pulmonary toxicity. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 hours/day, 5 days). Pulmonary damage and blood gene expression profiles were determined at various latency periods (0 - 16 weeks). Silica exposure resulted in pulmonary toxicity and this was evidenced by histological changes in the lungs and elevation of LDH activity, and total protein and albumin contents in the bronchoalveolar lavage fluid (BALF) of the rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS5197 GDS5198 GDS5199

Platform:

GPL6101

96 Samples

Download data: TXT

Analysis of blood samples from Fischer animals for up to 16 weeks following inhalation of crystalline silica at a concentration of 15 mg/m3, 6 h/day for 5 consecutive days. Results provide insight into the utility of blood gene expression profiling to detect pulmonary toxicity induced by silica.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 6 time sets

Platform:

GPL6101

Series:

GSE27023

72 Samples

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(Submitter supplied) The RatRef-12 Expression BeadChip includes twelve genome-scale, gene expression microarrays built using Illumina’s multi-sample Array of Arrays format. BeadChip content (22,523 probes per array) was selected from theNational Center for Biotechnology Information (NCBI) Reference Sequence (RefSeq) database. Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...

Organism:

Rattus norvegicus

7 DataSets

140 Series

2934 Samples

Download data: BGX