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(Submitter supplied) Background: Cardiac transcription factors are master regulators during heart development. Recently, some were shown to transdifferentiate noncardiac mesoderm cells and cardiac fibroblasts into cardiomyocytes. However, the individual roles of each transcription factors in activating cardiac gene program have not been elucidated. We examined cardiac-specific and genome-wide gene expression in fibroblasts induced with cardiac transcription factors Nkx2.5 (N), Tbx5 (T), Gata4 (G), Myocardin (M) alone or different combinations. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4328

Platform:

GPL1261

24 Samples

Download data: CEL

Analysis of 10T1/2-tTA fibroblasts infected with different combinations of cardiac transcription factors (TFs) Tbx5, Gata4, and Myocardin lentiviruses and induced with doxycycline for 14 days. Results provide insight into the specific roles of these TFs in activating cardiac gene programs.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 8 infection sets

Platform:

GPL1261

Series:

GSE27329

24 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4546 Series

40 Related Platforms

58941 Samples

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