GEO DataSets

(Submitter supplied) The mechanisms of diabetic neuropathy (DN) development and progression are not fully understood. We examined global gene expression in the sciatic nerve (SCN) of BKS-db/db mice at 8 and 24 weeks of age to identify genetic pathways altered in peripheral nerves at early and advanced stages of DN. The sets of differentially expressed genes were analyzed to identify enriched biological functions and regulated genetic pathways. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL9746

29 Samples

Download data: CEL

(Submitter supplied) A better understanding of the molecular mechanisms underlying the development and progression of diabetic neuropathy (DN) is essential for the design of mechanism-based therapies. We examined changes in global gene expression to define pathways regulated by diabetes in peripheral nerve. Microarray data for 24 week-old BKS db/db and db/+ mouse sciatic nerve were analyzed to define significantly differentially expressed genes (DEGs); DEGs were further used for functional enrichment analysis and network analysis to identify biological processes and pathways differentially regulated in the db/db nerve. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3993

Platform:

GPL9746

13 Samples

Download data: CEL

Analysis of sciatic nerve from type 2 diabetes (T2D) BKS db/db mice at 24 weeks of age. Diabetic neuropathy (DN) is one of the most common and debilitating complications of diabetes. Results provide insight into molecular mechanisms underlying the development and progression of DN.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 disease state, 2 genotype/variation sets

Platform:

GPL9746

Series:

GSE27382

13 Samples

Download data: CEL

(Submitter supplied) Custom CDF (Brainarray Entrez Gene v12.0.0) Protocol: see manufacturer's web site

Organism:

Mus musculus

1 DataSet

7 Series

1 Related Platform

87 Samples

Download data: CDF