GEO DataSets

(Submitter supplied) Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased screen with primary human HSCs identified a purine derivative, StemRegenin 1 (SR1), that promotes the ex vivo expansion of CD34+ cells. Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3911

Platform:

GPL570

8 Samples

Download data: CEL

Analysis of hematopoietic stem cells (HSC) treated with StemRegenin 1 (SR1) and LGC006 (a less potent SR1 analog) at 30nM to 1000nM. The use of HSC transplants depends on the ability to expand these cells ex vivo. Results provide insight into molecular basis of SR1-induced ex vivo HSC expansion.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 5 dose sets

Platform:

GPL570

Series:

GSE28359

8 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5671 Series

61 Related Platforms

175585 Samples

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