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Items: 4

1.

Tuberous sclerosis complex 1 (Tsc1) enforces quiescence of naive T cells to promote immune homeostasis and function

(Submitter supplied) The mechanisms that regulate T cell quiescence are poorly understood. We report that tuberous sclerosis complex 1 (Tsc1) establishes a quiescent program in naïve T cells by controlling cell size, cell cycle entry, and responses to T cell receptor stimulation. Loss of quiescence predisposed Tsc1-deficient T cells to apoptosis that depleted conventional T cells and invariant natural killer T cells. Loss of Tsc1 function dampened in vivo immune responses to bacterial infection. Tsc1-deficient T cells exhibited increased mTORC1 but diminished mTORC2 activities, with mTORC1 activation essential for the disruption of immune homeostasis. Therefore, Tsc1-dependent control of mTOR is crucial in establishing naïve T cell quiescence to facilitate adaptive immune function.
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4434 GDS4572
Platform:
GPL11180
16 Samples
Download data: CEL
Series
Accession:
GSE29797
ID:
200029797
2.
Full record GDS4572

Tuberous sclerosis complex 1 deficient naïve CD4 and CD8 T cells

Analysis of naïve CD4 and CD8 T cells deficient for Tuberous sclerosis complex 1 (Tsc1). Tsc1 tumor suppressor is an mTOR signaling modulator involved in naive T cell quiescence and immune homeostasis regulation. Results identify a Tsc1-dependent gene signature in naive T cells.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 cell type, 2 genotype/variation sets
Platform:
GPL11180
Series:
GSE29797
10 Samples
Download data: CEL
3.

[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Protocol: see manufacturer's web site
Organism:
Mus musculus
13 DataSets
289 Series
9 Related Platforms
7003 Samples
Download data
Platform
Accession:
GPL11180
ID:
100011180
4.

wild-type naïve CD8 T cells KAI284

Organism:
Mus musculus
Source name:
wild-type naïve CD8 T cells
Platform:
GPL11180
Series:
GSE29797
Dataset:
GDS4572
Download data: CEL
Sample
Accession:
GSM738382
ID:
300738382
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