GEO DataSets

(Submitter supplied) The mechanisms that regulate T cell quiescence are poorly understood. We report that tuberous sclerosis complex 1 (Tsc1) establishes a quiescent program in naïve T cells by controlling cell size, cell cycle entry, and responses to T cell receptor stimulation. Loss of quiescence predisposed Tsc1-deficient T cells to apoptosis that depleted conventional T cells and invariant natural killer T cells. Loss of Tsc1 function dampened in vivo immune responses to bacterial infection. Tsc1-deficient T cells exhibited increased mTORC1 but diminished mTORC2 activities, with mTORC1 activation essential for the disruption of immune homeostasis. Therefore, Tsc1-dependent control of mTOR is crucial in establishing naïve T cell quiescence to facilitate adaptive immune function.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4434 GDS4572

Platform:

GPL11180

16 Samples

Download data: CEL

Analysis of naïve CD4 and CD8 T cells deficient for Tuberous sclerosis complex 1 (Tsc1). Tsc1 tumor suppressor is an mTOR signaling modulator involved in naive T cell quiescence and immune homeostasis regulation. Results identify a Tsc1-dependent gene signature in naive T cells.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 cell type, 2 genotype/variation sets

Platform:

GPL11180

Series:

GSE29797

10 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Protocol: see manufacturer's web site

Organism:

Mus musculus

13 DataSets

289 Series

9 Related Platforms

7003 Samples

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