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Items: 3

1.

Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment

(Submitter supplied) Purpose: Cancer drug development is currently limited by a paradigm of preclinical evaluation that does not adequately recapitulate the complexity of the intact human tumor microenvironment (TME). To overcome this, we combined trackable intratumor microdosing (CIVOTM) with spatial biology readouts to directly assess drug effects in patient tumors in situ. Patients and Methods: In a first-of-its-kind Phase 0 clinical trial, we explored the effects of an investigational stage SUMOylation Activating Enzyme (SAE) inhibitor, subasumstat (TAK-981) in 12 patients with head and neck carcinoma (HNC). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL32550
354 Samples
Download data: TXT
Series
Accession:
GSE235475
ID:
200235475

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Cancer Transcriptomic Atlas, Human, 1812 genes, Nanostring GeoMx Digital Spatial Profiling (DSP) Platform

(Submitter supplied) See manfacturer's website
Organism:
Homo sapiens
2 Series
449 Samples
Download data
Platform
Accession:
GPL32550
ID:
100032550

3.

Patient 8 Slide B369 ROI 036

Organism:
Homo sapiens
Source name:
head and neck carcinoma
Platform:
GPL32550
Series:
GSE235475
Download data
Sample
Accession:
GSM7503046
ID:
307503046

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db=gds|term=GSM7503046[Accession]|query=1|qty=2|blobid=MCID_67597949df415c74f8c929d6|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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