GEO DataSets

(Submitter supplied) Amyotrophic lateral sclerosis (ALS) spares the ocular motor system. In this study, we tested the hypothesis that the oculomotor neurons are intrinsically protected in ALS. Using high-density cDNA microarrays, we examined the transcriptome of oculomotor nuclei and spinal cords in mice expressing a human mutant SOD1, the SOD1(G93A) ALS model, at 6 and 10 weeks of age. Comparison of gene expression profiles of these pre-symptomatic SOD1(G93A) mice showed a shift to a proapoptotic state in spinal cords, while the opposite was true in oculomotor nuclei. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1716

Platform:

GPL339

18 Samples

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Analysis of oculomotor motor neurons (OMNs) of SOD1-G93A transgenic model of amyotrophic lateral sclerosis (ALS) at 6 and 10 weeks of age. ALS spares the ocular neurons suggesting they are intrinsically protected against ALS. Results instead suggest OMNs actively adapt to the ALS-inducing mutation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 genotype/variation, 2 tissue sets

Platform:

GPL339

Series:

GSE3343

18 Samples

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(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip Mouse Genome 430A 2.0 Array is accessioned in GEO as GPL8321. June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Mouse Genome 430A Array is a single array representing approximately 14,000 well-characterized mouse genes that can be used to explore biology and disease processes. more...

Organism:

Mus musculus

142 DataSets

423 Series

2 Related Platforms

5328 Samples

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