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Items: 4

1.

DNA methylation status determines the sensitivity of repeats to restriction by the HUSH-MORC2 complex

(Submitter supplied) The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. However, how HUSH and MORC2 operate alongside DNA methylation, a central epigenetic regulator of repeat transcription, remains poorly understood. Here we interrogate this relationship in human neural progenitor cells (hNPCs), a somatic model of brain development that tolerates removal of DNA methyltransferase DNMT1. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24676 GPL18573 GPL26167
75 Samples
Download data: BW, TSV
Series
Accession:
GSE242143
ID:
200242143

2.

DNA methylation status determines the sensitivity of repeats to restriction by the HUSH-MORC2 complex [CUT&RUN]

(Submitter supplied) The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. However, how HUSH and MORC2 operate alongside DNA methylation, a central epigenetic regulator of repeat transcription, remains poorly understood. Here we interrogate this relationship in human neural progenitor cells (hNPCs), a somatic model of brain development that tolerates removal of DNA methyltransferase DNMT1. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
42 Samples
Download data: BW
Series
Accession:
GSE240384
ID:
200240384

3.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12651 Series
344593 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

4.

CR137_LV3599_Control_midXL_MORC2

Organism:
Homo sapiens
Source name:
Sai2
Platform:
GPL18573
Series:
GSE240384 GSE242143
Download data: BW
Sample
Accession:
GSM7697283
ID:
307697283

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db=gds|term=GSM7697283[Accession]|query=1|qty=2|blobid=MCID_675b0eac1fc51b7b01298742|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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