GSM7758132[Accession] - GEO DataSets

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Items: 4

Select item 2002431321.

METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL24676 GPL21145
73 Samples

Download data: BEDGRAPH, BW, IDAT, MTX, TSV

Series

Accession:: GSE243132

ID:: 200243132

PubMed Full text in PMC Similar studies

Select item 2002423262.

METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [ChIPseq]

(Submitter supplied) Glioblastomas are the most common malignant brain tumours in adults; they are highly aggressive, heterogeneous and plastic. We have identified METTL7B as an essential regulator of lineage specification in glioblastoma, with impact on both tumour size and invasiveness in in vivo models. Single cell transcriptomic analysis of these tumours and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B identified a regulatory role for the gene in the neural stem cells to astrocyte differentiation trajectory. more...