GEO DataSets

(Submitter supplied) The maintenance of advanced malignancies relies on continued activity of driver oncogenes, although their rate-limiting role is highly context-dependent with respect to tumor types and associated genetic alterations. Oncogenic Kras mutation is the signature event in human pancreatic ductal adenocarcinoma (PDAC), serving a critical role in tumor initiation. Here, an inducible KrasG12D-driven p53 mutant PDAC mouse model establishes that advanced PDAC remains strictly dependent on continued KrasG12D expression and that KrasG12D serves a vital role in the control of tumor metabolism, through stimulation of glucose uptake and channeling of glucose intermediates through the hexosamine biosynthesis pathway (HBP) and the pentose phosphate pathway (PPP). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4343

Platform:

GPL1261

33 Samples

Download data: CEL

Analysis of xenograft tumors generated from independent iKras p53L/+ PDAC cell lines. Cultured parental lines also examined. Doxycycline treatment induced expression of oncogenic KrasG12D. Results provide insight into the molecular mechanisms underlying KrasG12D-mediated PDAC tumor maintenance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 7 cell line, 3 cell type, 2 protocol sets

Platform:

GPL1261

Series:

GSE32277

33 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4547 Series

40 Related Platforms

58950 Samples

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