GSM801057[Accession] - GEO DataSets

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Items: 4

Select item 2000323501.

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9052 GPL6244
23 Samples

Download data: BED, CEL

Series

Accession:: GSE32350

ID:: 200032350

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000323492.

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin (ChIP-Seq)

(Submitter supplied) Multiple signaling pathways ultimately modulate the epigenetic information embedded in the chromatin of gene promoters by recruiting epigenetic enzymes. We found that, in estrogen-regulated gene programming, the acetyltransferase CREB-binding protein (CBP) is specifically and exclusively methylated by the coactivator-associated arginine methyltransferase (CARM1) in vivo. CARM1-dependent CBP methylation and p160 coactivators were required for estrogen-induced recruitment to chromatin targets. more...