GSM8072137[Accession] - GEO DataSets

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Items: 4

Select item 2002554161.

FOXO1 is a master regulator of CAR T memory programming

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
83 Samples

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Series

Accession:: GSE255416

ID:: 200255416

PubMed Full text in PMC Similar studies

Select item 2002554102.

FOXO1 is a master regulator of CAR T memory programming [RNA_FOXO1_KO]

(Submitter supplied) Poor CAR T persistence limits CAR T cell therapies for B cell malignancies and solid tumors1,2. The expression of memory-associated genes such as TCF7 (protein name TCF1) is linked to response and long-term persistence in patients3–7, thereby implicating memory programs in therapeutic efficacy. Here, we demonstrate that the pioneer transcription factor, FOXO1, is responsible for promoting memory programs and restraining exhaustion in human CAR T cells. more...