GEO DataSets

(Submitter supplied) Background: Mycobacterium avium subspecies paratuberculosis (MPTb) is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences. MPTb bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infection that can lead to immunopathology and disease dissemination. Consequently, analysis of the macrophage transcriptome in response to MPTb infection can provide valuable insights into the molecular mechanisms that underlie Johne’s disease. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Dataset:

GDS4518

Platform:

GPL2112

48 Samples

Download data: CEL

Analysis of monocyte-derived macrophages isolated from Holstein-Friesian females in response to M. avium subsp. paratuberculosis (MPTb) infection in vitro for up to 24hrs. MPTb is the etiological agent of Johne's disease. Results provide insight into the molecular basis of the host immune response.

Organism:

Bos taurus

Type:

Expression profiling by array, transformed count, 2 infection, 4 time sets

Platform:

GPL2112

Series:

GSE35185

48 Samples

Download data: CEL

(Submitter supplied) Background: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cells types to encounter M. bovis following exposure and the response elicited by these cells is pivotal in determining the outcome of infection. Here, a functional genomics approach was undertaken to investigate global gene expression profiles in bovine monocyte-derived macrophages (MDM) purified from seven age-matched non-related females, in response to in vitro challenge with M. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL2112

49 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip Bovine Genome Array can be used to study gene expression of over 23,000 bovine transcripts. The array is an ideal tool for researchers studying gene expression profiles in cattle. With the broadest representation of publicly available expressed sequence information, bovine researchers will be able to use this array to monitor genetic mechanisms regulating a variety of preferred traits, such as: - Disease resistance - Meat and dairy production - Stress tolerance The Bovine Genome Array was designed in close collaboration with the Bovine Research Community as part of the Affymetrix GeneChip Consortia Program. more...

Organism:

Bos taurus

8 DataSets

134 Series

3 Related Platforms

2304 Samples

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